Methyl iodide → HCID 21434697, compound

HRID 2398081Notes

Reaction equation

HRID 2398081 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[N:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=[C:4]2[CH:3]=1.[H-].[Na+].[CH3:23]I>CN(C)C=O>[CH3:23][O:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[N:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=[C:4]2[CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 178515399HCID 178515399, compound

Product 1

HCID 21434697HCID 21434697, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

One gram (0.00383 mole) of the compound of Example 1 is dissolved at 60° C. in 30 ml. of dimethylformamide, the resulting solution is brought to room temperature, then 0.2 g. of a 50% oily suspension of sodium hydride is added. After 1 hour, 0.25 ml. (0.004 mole) of methyl iodide is added and the obtained mixture is stirred for 5 hours and concentrated to dryness. The obtained residue is taken up with water and recrystallized from ethanol. Yield, 0.55 g., m.p., 144°-145° C.

Workup

  1. customis brought to room temperature
  2. concentrationconcentrated to dryness
  3. customrecrystallized from ethanol
  4. customYield
  5. customm.p., 144°-145° C.

Sources & evidence

ORD record
ord-87cae18414d34d4d895e610a46ecb4e8
Source dataset
uspto-grants-1977_05
Patent number
US04024149

Reaction notes

Loading…