反应详情

温度

10 °C

In 9 l of water at 30° C. were dissolved 218 g of 12-aminododecanoic acid and 100 g of sodium hydroxide (purity: 93%), and 102 ml of methacryl chloride was added thereto over 1 hour while stirring. The reaction mixture was stirred for 2 hours and then heated to 60° C., at which 3 l of ethyl acetate and 300 ml of concentrated hydrochloric acid were added thereto successively. The mixture was filtered while hot (60° C.) to remove any insoluble matter, followed by liquid-liquid separation. The organic layer was dried over 30 g of magnesium sulfate and, after removal of the magnesium sulfate, cooled to 10° C., at which 6 l of n-hexane was added, whereupon a precipitate was formed. The precipitate was collected by filtration and thoroughly washed with 1 l of n-hexane. Recrystallization of the precipitate from 500 ml of ethyl acetate yielded 128 g of 12-methacryloylaminododecanoic acid.

1. additionwas added
2. stirringThe reaction mixture was stirred for 2 hours
3. additionwere added
4. filtrationThe mixture was filtered while hot (60° C.)
5. customto remove any insoluble matter
6. customfollowed by liquid-liquid separation
7. dry with materialThe organic layer was dried over 30 g of magnesium sulfate
8. customafter removal of the magnesium sulfate
9. additionwas added, whereupon a precipitate
10. customwas formed
11. filtrationThe precipitate was collected by filtration
12. washthoroughly washed with 1 l of n-hexane
13. customRecrystallization of the precipitate from 500 ml of ethyl acetate