Triethylamine → 2-(7-Methoxynaphthalen-1-yl)acetonitrile

HRID 2399392Notes

Reaction equation

HRID 2399392 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]([NH2:16])=O)=[CH:5][CH:4]=1.C(N(CC)CC)C.FC(F)(F)C(OC(=O)C(F)(F)F)=O>O1CCCC1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]#[N:16])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 151491272-(7-Methoxynaphthalen-1-yl)acetamide

Product 1

HCID 112640682-(7-Methoxynaphthalen-1-yl)acetonitrile

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The (7-methoxynaphth-1-yl)acetamide obtained in step E is suspended in 80 cm3 of anhydrous tetrahydrofuran. Triethylamine is added. The solution is cooled in an ice bath, and then trifluoroacetic anhydride is added dropwise, with magnetic stirring.

Workup

  1. temperatureThe solution is cooled in an ice bath

Sources & evidence

ORD record
ord-34262f963e664b649ca9fc7c12f58f2f
Source dataset
uspto-grants-1995_09
Patent number
US05449690

Reaction notes

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