Tetrahydrofuran → HCID 19384529, compound

HRID 2399801Notes

Reaction equation

HRID 2399801 reaction equation
C1(CO[C:9]2[CH:10]=[CH:11][CH:12]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[C:13]3[C:17]=2[N:16]=[C:15]2CCCC[C:14]=32)C=CC=CC=1.[O:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1>C(OCC)(=O)C>[F:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][CH:12]2[C:13]3[C:31]4[CH:32]=[CH:33][C:34]([OH:30])=[CH:14][C:15]=4[NH:16][C:17]=3[CH2:9][CH2:10][CH2:11]2)=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 19384468HCID 19384468, compound

Product 1

HCID 19384529HCID 19384529, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The hydrogenation of 2.8 g of 1,2,3,4-tetrahydro-6-phenylmethoxy -9-[(4-fluorophenyl)methyl]-9H-dibenzo[b,d]pyrrole from Example 77 was carried out by using the procedure described in Example 86 except that 1:1 tetrahydrofuran-absolute ethyl alcohol was used instead of 1:1 ethyl acetate-absolute ethyl alcohol mixture as a solvent. The crude 5,6,7,8-tetrahydro-9-[(3-fluorophenyl)methyl]-9H-dibenzo[b,d]pyrrol-3-ol was used without further purification.

Workup

  1. customThe crude 5,6,7,8-tetrahydro-9-[(3-fluorophenyl)methyl]-9H-dibenzo[b,d]pyrrol-3-ol was used without further purification

Sources & evidence

ORD record
ord-8d4a966864314047a81b41e061049b4b
Source dataset
uspto-grants-1995_09
Patent number
US05451600

Reaction notes

Loading…