Hydrochloric Acid → HCID 67027545, compound

HRID 2400349Notes

Reaction equation

HRID 2400349 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]3[C:14]([C:17]4[CH:18]=[C:19]([NH:23][C:24]([NH:26][CH2:27][C:28]([F:31])([F:30])[F:29])=[O:25])[CH:20]=[CH:21][CH:22]=4)=[CH:15][N:16]=[C:10]3[CH:9]=2)[CH:5]=[C:4]([N:32]2[CH2:37][CH2:36][N:35]([CH2:38][CH2:39][O:40]C3CCCCO3)[CH2:34][CH2:33]2)[N:3]=1.Cl>CCOC(C)=O>[OH:40][CH2:39][CH2:38][N:35]1[CH2:36][CH2:37][N:32]([C:4]2[N:3]=[C:2]([CH3:1])[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][N:11]4[C:14]([C:17]5[CH:18]=[C:19]([NH:23][C:24]([NH:26][CH2:27][C:28]([F:29])([F:30])[F:31])=[O:25])[CH:20]=[CH:21][CH:22]=5)=[CH:15][N:16]=[C:10]4[CH:9]=3)[CH:5]=2)[CH2:33][CH2:34]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67027744HCID 67027744, compound

Product 1

HCID 67027545HCID 67027545, compoundYield 23%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 1-{3-[7-(2-Methyl-6-{4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-piperazin-1-yl}-pyrimidin-4-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea (150 mg) treated with saturated HCl in EtOAc, reaction stirred RT for 1 hour, precipitated solid filtered and washed with EtOAc. The crude product was purified by preparative HPLC twice to give product (30 mg).

Workup

  1. customprecipitated solid
  2. filtrationfiltered
  3. washwashed with EtOAc
  4. customThe crude product was purified by preparative HPLC twice

Sources & evidence

ORD record
ord-5b41c75b10234deca331562763cb031a
Source dataset
uspto-grants-2014_08
Patent number
US08796244B2

Reaction notes

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