反应详情

温度

100 °C

1-[2-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]methanamine (Intermediate 5, 100 mg, 0.465 mmol), 6-chloro-4-pyrimidinecarbonitrile (Intermediate 8, 97 mg, 0.697 mmol) and DIPEA (0.162 mL, 0.929 mmol) were added together in N-methyl-2-pyrrolidone (2 mL) and the resulting mixture was heated at 100° C. for 2 hours and allowed to cool to room temperature. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic layer was separated, dried under magnesium sulfate and evaporated under reduced pressure. The residue was purified by MDAP. Product containing fractions were combined and evaporated under reduced pressure. The resulting solid was dried under high vacuum at 45° C. for 18 hours to give the title compound as an off-white solid (32 mg);

1. temperatureto cool to room temperature
2. washwashed with water and brine
3. customThe organic layer was separated
4. customdried under magnesium sulfate
5. customevaporated under reduced pressure
6. customThe residue was purified by MDAP
7. additionProduct containing fractions
8. customevaporated under reduced pressure
9. customThe resulting solid was dried under high vacuum at 45° C. for 18 hours