反应详情

44 g of ethyl 6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylate (Example 15A; 115.5 mmol, 1 equivalent) were dissolved in 550 ml of THF and 700 ml of methanol, 13.8 g of lithium hydroxide (dissolved in 150 ml of water; 577 mmol, 5 equivalents) were added and the mixture was stirred at RT overnight. 1 N aqueous hydrochloric acid was added to the reaction mixture, and the mixture was concentrated. The solid obtained was filtered off and washed with water. This gave 34 g of the title compound (84% of theory).

1. concentrationthe mixture was concentrated
2. customThe solid obtained
3. filtrationwas filtered off
4. washwashed with water