反应详情

Benzyl bromide (0.86 ml, 7.9 mmol) was added to a mixture of 6-aminonicotinic acid (1.0 g, 7.2 mmol) and potassium carbonate (1.5 g, 10.8 mmol) in DMF (4 mL). The mixture was stirred at room temperature for 16 hr and diluted with water (50 mL). The aqueous mixture was extracted with ethyl acetate (1×). The EtOAc layer was washed with brine, dried over MgSO4 and concentrated to provide crude solid product. Recrystallization from diethyl ether provided the title compound as a pale yellow solid (0.88 g, 53%).

1. extractionThe aqueous mixture was extracted with ethyl acetate (1×)
2. washThe EtOAc layer was washed with brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customto provide crude solid product
6. customRecrystallization from diethyl ether