反应详情

温度

45 °C

To a suspension of magnesium (1.8 g, 74 mmol) in dry THF (50 mL) in a flame-dried round bottomed flask under nitrogen was added 4-chloro-1-methylpiperidine (9.0 g, 68 mmol). A crystal of iodine and a catalytic amount of cyclohexylmagnesium chloride was added and the mixture was heated to reflux for 2 h. A gray precipitate formed, which was removed via vacuum filtration under a nitrogen atmosphere. To the filtrate was added a solution of 2-aminobenzonitrile (1.6 g, 14 mmol) in dry THF (15 mL). The stirred mixture was heated to 45° C. for 2 h. Ice was added and the reaction was quenched with 1 M sulfuric acid. The mixture was extracted with ethyl acetate and the acidic aqueous layer was then neutralized with 1 N sodium hydroxide, concentrated on a rotary evaporator and extracted with ethyl acetate. The combined organics were dried over sodium sulfate, filtered and concentrated to afford (2-aminophenyl)(1-methylpiperidin-4-yl)methanone as a yellow oil (1.0 g, 7%).

1. temperaturethe mixture was heated
2. temperatureto reflux for 2 h
3. customA gray precipitate formed
4. customwhich was removed via vacuum filtration under a nitrogen atmosphere
5. additionIce was added
6. customthe reaction was quenched with 1 M sulfuric acid
7. extractionThe mixture was extracted with ethyl acetate
8. concentrationconcentrated on a rotary evaporator
9. extractionextracted with ethyl acetate
10. dry with materialThe combined organics were dried over sodium sulfate
11. filtrationfiltered
12. concentrationconcentrated