反应详情

To a solution of 150 mg (0.67 mmol) of ethyl 3-(4-aminophenyl)-3-methoxypropionate, 116 mg (1.01 mmol) of N-ethylmorpholine, 123 mg (0.81 mmol) of HOBt hydrate and 125 mg (0.81 mmol) of EDAC in 2 ml of DMF was added a solution of 212 mg (0.74 mmol) of 2-(2-bromo-4-isopropylphenoxy)propionic acid in 2 ml of DMF. After 22 h at room temperature, the reaction mixture was diluted with sodium chloride solution and extracted with ethyl acetate. The organic phase was dried over MgSO4, filtered and concentrated under reduced pressure. This gave 331 mg of ethyl 3-{4-[2-(2-bromo-4-isopropylphenoxy)propionylamino]phenyl}-3-methoxypropionate.

1. extractionextracted with ethyl acetate
2. dry with materialThe organic phase was dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure