Hydrochloric Acid → HCID 776593, compound

HRID 2404944Notes

Reaction equation

HRID 2404944 reaction equation
[CH:1]1([C:4](Cl)=[O:5])[CH2:3][CH2:2]1.[CH2:7]([O:9][C:10]([C:12]1[C:13]2[CH2:21][CH2:20][CH2:19][CH2:18][C:14]=2[S:15][C:16]=1[NH2:17])=[O:11])[CH3:8].Cl>N1C=CC=CC=1>[CH2:7]([O:9][C:10]([C:12]1[C:13]2[CH2:21][CH2:20][CH2:19][CH2:18][C:14]=2[S:15][C:16]=1[NH:17][C:4]([CH:1]1[CH2:3][CH2:2]1)=[O:5])=[O:11])[CH3:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 77637Cyclopropanecarbonyl chlorideHCID 78262Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Product 1

HCID 776593HCID 776593, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

11 millimol cyclopropanecarbonyl chloride was added dropwise to the solution of 10 millimol IV in 25 milliliter pyridine at 5° C. The reaction mixture was stirred at this temperature for 1 hour, poured onto icecold 1N aqueous HCl, the precipitated solid was filtered off, washed with water and n-hexane, then dried.

Workup

  1. filtrationthe precipitated solid was filtered off
  2. washwashed with water and n-hexane
  3. customdried

Sources & evidence

ORD record
ord-b298b8a145d54ecc8e23550490f3cb51
Source dataset
uspto-grants-2014_08
Patent number
US08802849B2

Reaction notes

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