Dimethylformamide → 5,6-Dichloro-1-pyridin-2-ylmethyl-2-(2-trifluoromethyl-[1,3]dioxin-2-yl)-1H-benzimidazole

HRID 2405074Notes

Reaction equation

HRID 2405074 reaction equation
[Cl:1][C:2]1[C:19]([Cl:20])=[CH:18][C:5]2[NH:6][C:7]([C:9]3([C:14]([F:17])([F:16])[F:15])[O:13][CH2:12][CH2:11][O:10]3)=[N:8][C:4]=2[CH:3]=1.[H-].[Na+].Br.Br[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=1.[CH3:32]N(C=O)C>C(OCC)(=O)C.C(OCC)C>[Cl:1][C:2]1[C:19]([Cl:20])=[CH:18][C:5]2[N:6]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)[C:7]([C:9]3([C:14]([F:16])([F:15])[F:17])[O:10][CH2:11][CH:32]=[CH:12][O:13]3)=[N:8][C:4]=2[CH:3]=1

Participants

7

Reactant 4

HCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 166648615,6-Dichloro-2-(2-trifluoromethyl-[1,3]dioxolan-2-yl)-1H-benzimidazole

Product 1

HCID 671034665,6-Dichloro-1-pyridin-2-ylmethyl-2-(2-trifluoromethyl-[1,3]dioxin-2-yl)-1H-benzimidazole

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

5,6-Dichloro-2-(2-trifluoromethyl-[1,3]dioxolan-2-yl)-1H-benzimidazole (0.37 g; 1.1 mmol) was dissolved in DMF (6 mL), treated with 60% NaH in mineral oil 9.14 g; 3.5 mmol) and stirred under a nitrogen atmosphere for 20 minutes. Subsequently, 2-(Bromomethyl)pyridine hydrobromide (0.44 g; 1.7 mmol) was added to the reaction mixture and stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate (25 mL) and diethyl ether (25 mL), washed with water (30 mL) and brine (3×30 mL), then dried over Na2SO4. The concentrated crude material was purified by column chromatography (SiO2; 50% ethyl acetate/hexanes) to yield the title compound as an off-white solid.

Workup

  1. stirringstirred at room temperature overnight
  2. washwashed with water (30 mL) and brine (3×30 mL)
  3. dry with materialdried over Na2SO4
  4. concentrationThe concentrated crude material
  5. customwas purified by column chromatography (SiO2; 50% ethyl acetate/hexanes)

Sources & evidence

ORD record
ord-3e6f53c1c6ae425b88b8294d3583b7e3
Source dataset
uspto-grants-2014_08
Patent number
US08802865B2

Reaction notes

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