反应详情

温度

25 °C

According to the above-described scheme, 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester (Compound 2f; 279.1 mg, 1.0 mmol), 1N K2CO3 solution (3.0 mL) and DMF (3.0 mL) were put into an eggplant flask, and the mixture was stirred at 25° C. for 18 hours. After the reaction, the reaction mixture was neutralized with 5% HCl solution, extracted with ethyl acetate and washed with water, and an organic layer was dried with anhydrous sodium sulfate. Ethyl acetate was distilled away under reduced pressure, and by carrying out purification by silica gel column chromatography, 2-(4-bromophenyl)-2,2-difluoroacetic acid (Compound 4f) was obtained with a yield of 85%.

1. customwere put into an eggplant flask
2. customAfter the reaction
3. extractionextracted with ethyl acetate
4. washwashed with water
5. dry with materialan organic layer was dried with anhydrous sodium sulfate
6. distillationEthyl acetate was distilled away under reduced pressure
7. custompurification by silica gel column chromatography