Diisopropylethylamine → HCID 178431648, compound

HRID 2405694Notes

Reaction equation

HRID 2405694 reaction equation
CCN(C(C)C)C(C)C.Br[CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14].[CH3:17][C:18]1([CH3:51])[O:23][C:22]([NH:24][C:25]23[CH2:32][CH:31]4[CH2:33][C:27]([C:34]([NH2:36])=[O:35])([CH2:28][CH:29]2[CH2:30]4)[CH2:26]3)=[N:21][S:20](=[O:38])(=[O:37])[C@@H:19]1[C:39]1[CH:44]=[CH:43][C:42]([CH:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)=[CH:41][CH:40]=1>CN(C=O)C>[CH3:17][C:18]1([CH3:51])[O:23][C:22]([NH:24][C:25]23[CH2:32][CH:31]4[CH2:33][C:27]([C:34]([NH2:36])=[O:35])([CH2:28][CH:29]2[CH2:30]4)[CH2:26]3)=[N:21][S:20](=[O:37])(=[O:38])[C@@H:19]1[C:39]1[CH:40]=[CH:41][C:42]([CH:45]2[CH2:50][CH2:49][N:48]([CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14])[CH2:47][CH2:46]2)=[CH:43][CH:44]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 178431647HCID 178431647, compound

Product 1

HCID 178431648HCID 178431648, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

DIPEA (75 mg) and 3-bromo-1,1,1-trifluoropropane (500 mg) were added to a solution of 3a-[(R)-6,6-dimethyl-4,4-dioxo-5-(4-piperidin-4-yl-phenyl)-5,6-dihydro-4H-4lambda*6*-[1,4,3]oxathiazin-2-ylamino]hexahydro-2,5-methanopentalene-2-carboxamide (73 mg) in DMF (1.5 mL), and the mixture was stirred overnight. The resulting mixture was purified in a purification laboratory by means of preparative HPLC. This gave the product with a molecular weight of 596.7 g/mol (C29H39F3N4O4S); MS (ESI): m/e=597 (M+H+).

Workup

  1. customThe resulting mixture was purified in a purification laboratory by means of preparative HPLC
  2. customThis gave the product with a molecular weight of 596.7 g/mol (C29H39F3N4O4S)

Sources & evidence

ORD record
ord-1bf3acc0a5cc46b6b092451dcd737ea5
Source dataset
uspto-grants-2014_08
Patent number
US08809324B2

Reaction notes

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