Hydrochloric Acid → HCID 58413161, compound

HRID 240657Notes

Reaction equation

HRID 240657 reaction equation
C[O:2][C:3]([C:5]1[S:27][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[C:15]([O:20][C@@H:21]4[CH2:26][CH2:25][CH2:24][O:23][CH2:22]4)=[N:16][CH:17]=[CH:18][CH:19]=3)[C:7]=2[C:6]=1[CH3:28])=[O:4].CO.[OH-].[Na+].Cl>O.C1COCC1>[CH3:28][C:6]1[C:7]2[C:12]([NH:13][C:14]3[C:15]([O:20][C@@H:21]4[CH2:26][CH2:25][CH2:24][O:23][CH2:22]4)=[N:16][CH:17]=[CH:18][CH:19]=3)=[N:11][CH:10]=[N:9][C:8]=2[S:27][C:5]=1[C:3]([OH:4])=[O:2]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 58413036HCID 58413036, compound

Product 1

HCID 58413161HCID 58413161, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1.4 g (3.14 mmol) 5-methyl-4-{2-[(R)-(tetrahydro-pyran-3-yl)oxy]-pyridin-3-ylamino}-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester, 20 ml methanol, 7 ml THF and 6.29 ml sodium hydroxid solution (1 M) was stirred at room temperature for 48 hours. Then 6.3 ml hydrochloric acid solution (1M) were added followed by addition of water. The mixture was filtered. The solid was washed with water and diisopropylether and dried in an oven (vacuo).

Workup

  1. filtrationThe mixture was filtered
  2. washThe solid was washed with water and diisopropylether
  3. customdried in an oven (vacuo)

Sources & evidence

ORD record
ord-a3840c4d87a74ed19b0b948ca86a5636
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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