反应详情

Triethylamine (53 μl) and 2-methoxyethylamine (23 mg) were added to a tetrahydrofuran (2 ml) solution containing 3-bromo-2-chloro-5-nitropyridine (60 mg), followed by stirring at room temperature for 1 hour. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate. Subsequently, the solvent was distilled away under reduced pressure, the obtained residue was purified by silica gel chromatography (n-hexane:ethyl acetate=6:1 to 3:1), and a light yellow solid of 3-bromo-N-(2-methoxyethyl)-5-nitropyridin-2-amine (93.5 mg) was thus obtained.

1. extractionfollowed by extraction with ethyl acetate
2. washThe resultant was washed with saturated saline
3. dry with materialdried over anhydrous sodium sulfate
4. distillationSubsequently, the solvent was distilled away under reduced pressure
5. customthe obtained residue was purified by silica gel chromatography (n-hexane:ethyl acetate=6:1 to 3:1)