反应详情

温度

40 °C

In a 25 mL round-bottomed flask, the above prepared 5-(tetrahydro-pyran-4-yl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid methyl ester (538 mg, 1.69 mmol, Eq: 1.00) was combined with tetrahydrofuran (4 ml) and water (2 ml) to give a colorless solution. Lithium hydroxide (80.7 mg, 3.37 mmol, Eq: 2) was added and the reaction mixture was stirred at 40° C. TLC after 3 h showed that the reaction was complete. 6 ml H2O and 4.5 ml 1N HCl were added and the white suspension was stirred for 10 min at 0° C. The solid was filtered off, washed with H2O and dried on hv to yield 489 mg of the title compound as white solid; MS (EI) 304.2 (M−H)−.

1. customto give a colorless solution
2. stirringthe white suspension was stirred for 10 min at 0° C
3. filtrationThe solid was filtered off
4. washwashed with H2O
5. customdried on hv