反应详情

N-Chlorosuccinimide (56.1 g) was added slowly to a 0° C. solution of the compound prepared in Example 4 (65.4 g) in N,N-dimethylformamide (1.2 L). The reaction was stirred at room temperature overnight and then diluted with ice water and methyl tert-butyl ether. The layers were separated and the aqueous phase was extracted once more with methyl tert-butyl ether. The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate and concentrated to obtain the title compound (79.5 g) having the following physical data.

1. customThe layers were separated
2. extractionthe aqueous phase was extracted once more with methyl tert-butyl ether
3. washwashed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated