反应详情

温度

70 °C

The compound ‘carbamic acid 3-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-1-phenyl-propyl ester (2 mmol) prepared in Example 84 was dissolved in tetrahydrofuran (25 mL), and potassium carbonate (K2CO3, 2.4 mmol) and benzylbromide (2.4 mmol) were added thereto, and the resulting mixture was stirred at 70° C. for 10 hours. The reaction mixture was diluted with water, and extracted several times with ethyl acetate to obtain an organic phase. The prepared organic phase was dried over magnesium sulfate, and concentrated under a reduced pressure. The resulting pellet was purified with column chromatography (hexane:ethyl acetate=1:1) to obtain a title compound.

1. extractionextracted several times with ethyl acetate
2. customto obtain an organic phase
3. dry with materialThe prepared organic phase was dried over magnesium sulfate
4. concentrationconcentrated under a reduced pressure
5. customThe resulting pellet was purified with column chromatography (hexane:ethyl acetate=1:1)