反应详情

温度

130 °C

5-Chloro-2-nitroaniline (50 g; 0.29 mol) was added to a 5 bomb followed by ethanol (1.1 L) at 0-5° C. Dimethylamine hydrochloride (130 g; 1.59 mmol) was added in one portion followed by triethylamine (260 ml) and the bomb quickly sealed. The bomb was heated to 130° C. with stirring at 4 bar for 20 hours. The reaction mixture was then allowed to cool to room temperature and the ethanol was removed under vacuum. 2 M sodium hydroxide solution (1 L) was added to the crude residue and this was extracted with ethyl acetate (1×1.3 L then 2×500 ml). The combined organic layers were washed with brine (150 ml), dried (magnesium sulphate), filtered and evaporated to give the 5-dimethylamino-2-nitroaniline (50.1 g, 96%).

1. customthe bomb quickly sealed
2. temperatureto cool to room temperature
3. customthe ethanol was removed under vacuum
4. addition2 M sodium hydroxide solution (1 L) was added to the crude residue
5. extractionthis was extracted with ethyl acetate (1×1.3 L
6. washThe combined organic layers were washed with brine (150 ml)
7. dry with materialdried (magnesium sulphate)
8. filtrationfiltered
9. customevaporated