Hydrochloric Acid → HCID 69316976, compound

HRID 2410334Notes

Reaction equation

HRID 2410334 reaction equation
[CH2:1]([O:5][C:6]1[C:11]2[C:12]([O:15][CH2:16][CH:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)=[N:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3].[ClH:30]>C(OCC)(=O)C>[Cl-:30].[CH2:1]([O:5][C:6]1[C:11]2[C:12]([O:15][CH2:16][CH:17]3[CH2:22][CH2:21][NH2+:20][CH2:19][CH2:18]3)=[N:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69321859HCID 69321859, compound

Product 1

HCID 69316976HCID 69316976, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a flask containing tert-butyl 4-{[(4-isobutyoxy-1,2-benzisoxazol-3-yl)oxy]methyl}piperidine-1-carboxylate (98.2 mg, 0.24 mmol, EXAMPLE 1, step 3) was added 4N solution of hydrogen chloride in ethyl acetate (1 mL) at room temperature. After being stirred for 2 h, solvent was evaporated and the residual solid was washed with ethyl acetate to give the title compound (62.4 mg, 75%) as a white solid.

Workup

  1. customsolvent was evaporated
  2. washthe residual solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-5ac59cc0332145ecbc977f3c6d7abdcb
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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