反应详情

温度

80 °C

1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione (172 mg) described in Example 448 was dissolved in 1,2-dichloroethane (5 mL), trifluoromethanesulfonic acid (0.18 mL) was added, and the mixture was stirred at 80° C. for 30 min. To the reaction mixture was added 5% aqueous sodium hydrogen carbonate solution, and the mixture was extracted with chloroform/methanol (10:1). The organic layer was dried over sodium sulfate, and the solvent was evaporated. The obtained residue was purified by silica gel column chromatography (ethyl acetate:methanol) to give the title compound (92 mg).

1. extractionthe mixture was extracted with chloroform/methanol (10:1)
2. dry with materialThe organic layer was dried over sodium sulfate
3. customthe solvent was evaporated
4. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate:methanol)