Potassium Iodide → HCID 54104364, compound

HRID 2413901Notes

Reaction equation

HRID 2413901 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:8][C:9]([CH2:12][CH2:13][CH2:14][CH2:15]Cl)=[CH:10][CH:11]=2)[N:6]=1.[C:17]1([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>O.CN(C)C=O>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:8][C:9]([CH2:12][CH2:13][CH2:14][CH2:15][N:26]3[CH2:27][CH2:28][N:23]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[CH2:24][CH2:25]3)=[CH:10][CH:11]=2)[N:6]=1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 70961-PhenylpiperazineHCID 11430Potassium CarbonateHCID 20154246HCID 20154246, compound

Product 1

HCID 54104364HCID 54104364, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 5.43 g of 2-amino-4-[5-(4-chlorobutyl)-2-thienyl]thiazole, 4.0 g of 4-phenylpiperazine, 3.2 g of potassium carbonate, 0.1 g of potassium iodide and 50 ml of dimethylformamide is stirred at 70°-80° C. for 15 hours. The resultant mixture is poured into water and extracted with water. The extract is washed with water and dried over magnesium sulfate. After the solvent is distilled off under reduced pressure, the residue is recrystallized from ethanol to give 2-amino-4-[5-(4-(4-phenyl-1-piperazinyl) butyl)-2-thienyl]thiazole, melting at 165°-167° C.

Workup

  1. extractionextracted with water
  2. washThe extract is washed with water
  3. dry with materialdried over magnesium sulfate
  4. distillationAfter the solvent is distilled off under reduced pressure
  5. customthe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-e560339a07fc4978be53838fd78e622d
Source dataset
uspto-grants-1988_01
Patent number
US04720493

Reaction notes

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