Acetic Acid → Ethyl 4-acetoxyacetoacetate

HRID 2413988Notes

Reaction equation

HRID 2413988 reaction equation
Cl[CH2:2][C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:11]([OH:14])(=[O:13])[CH3:12].C(N(CC)CC)C>CC(O)CC>[C:11]([O:14][CH2:2][C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])(=[O:13])[CH3:12]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 8471TriethylamineHCID 69484Ethyl 4-chloroacetoacetate

Product 1

HCID 11480907Ethyl 4-acetoxyacetoacetate

Reagents, catalysts & solvents 1

HCID 6568(+-)-2-ButanolSolvent

Procedure

71 ml of ethyl 4-chloro-3-oxobutyrate are reacted with 57 ml of acetic acid and 132 ml of triethylamine in 1 l of 2-butanol by the procedure described in Example 1.

Sources & evidence

ORD record
ord-f6b421cc26244dbd8e6ba71f1e066481
Source dataset
uspto-grants-1988_01
Patent number
US04720572

Reaction notes

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