Isopropanol → HCID 86759548, compound

HRID 2414232Notes

Reaction equation

HRID 2414232 reaction equation
Cl.[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5].[S:14]([O-:18])([OH:17])(=[O:16])=[O:15].[Na+:19].C(O)(C)C>O>[Na+:19].[S:14]([O-:18])([O-:17])(=[O:16])=[O:15].[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5].[Na+:19]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 516919Sodium BisulfateHCID 2723635(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol hydrochloride

Product 1

HCID 86759548HCID 86759548, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Glucosamine hydrochloride (6.45 g, 0.03 mol) and sodium hydrogen sulphate (1.8 g, 0.015 mol) were taken in a flask and dissolved in water (25 ml). The resulting solution was added dropwise to vigorously stirred isopropanol(150 ml) at room temperature over a period of one hour. The contents in the flask were further stirred for 4 hrs and then kept at 0° C.-5° C. for 16 hrs. The precipitate was filtered under vacuum (150 mm Hg). The product was washed twice (each time with 25 ml of isopropanol).

Workup

  1. waitkept at 0° C.-5° C. for 16 hrs
  2. filtrationThe precipitate was filtered under vacuum (150 mm Hg)
  3. washThe product was washed twice (each time with 25 ml of isopropanol)

Sources & evidence

ORD record
ord-c24774c4326a4607b05d9d6316466847
Source dataset
uspto-grants-2004_11
Patent number
US06812223B2

Reaction notes

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