Isopropylamine → 6-chloro-N-isopropylnicotinamide

HRID 2414312Notes

Reaction equation

HRID 2414312 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH:23]([NH2:26])([CH3:25])[CH3:24]>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:26][CH:23]([CH3:25])[CH3:24])=[O:8])=[CH:9][CH:10]=1

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 682631,1'-CarbonyldiimidazoleHCID 792226-Chloronicotinic acid

Product 1

HCID 8193696-chloro-N-isopropylnicotinamide

Procedure

The product was prepared from 6-chloro-nicotinic acid (1.0 g), carbonyldiimidazole (0.8 g) and isopropylamine (0.6 ml) using the method of example 115 step (i). Yield 0.75 g.

Sources & evidence

ORD record
ord-e19bc57ace4540c9ae4f0e0941251e64
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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