Triethylamine → HCID 10473439, compound

HRID 2415453Notes

Reaction equation

HRID 2415453 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][O:7][C:8]2[CH:9]=[CH:10][C:11](I)=[C:12]([CH2:14][C:15]([NH:17][C@H:18]([CH3:22])[C:19]([NH2:21])=[O:20])=[O:16])[CH:13]=2)=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:33](OCC)(=[O:35])C>[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[F:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][O:7][C:8]2[CH:13]=[C:12]3[C:11](=[CH:10][CH:9]=2)[C:33](=[O:35])[N:17]([C@H:18]([CH3:22])[C:19]([NH2:21])=[O:20])[C:15](=[O:16])[CH2:14]3)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 69036512HCID 69036512, compound

Product 1

HCID 10473439HCID 10473439, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 10122028Bis(triphenylphosphine)palladiumCatalyst

Procedure

As described for example 20f, the title compound (10 mg, 25%) was prepared from a mixture of 2-(R)-{2-[5-(4-Fluoro-benzyloxy)-2-iodo-phenyl]-acetylamino}-propionamide (50 mg, 0.109 mmol), triethylamine (0.030 mL, 0.218 mmol), bis (triphenylphosphine) palladium II chloride (1.5 mg, 0.0022 mmol) in 1 mL ethyl acetate. MS: m/e=357.2 (M+H+).

Sources & evidence

ORD record
ord-65544c9976a445d892f80542377efe56
Source dataset
uspto-grants-2004_11
Patent number
US06818774B2

Reaction notes

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