Hydrochloric Acid → Hydrochloric Acid

HRID 2415466Notes

Reaction equation

HRID 2415466 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([OH:17])=[CH:7][CH:8]=2)[N:3]=1.[CH:18]1([CH2:21]Br)[CH2:20][CH2:19]1.[ClH:23]>>[ClH:23].[ClH:23].[CH:18]1([CH2:21][O:17][C:6]2[CH:5]=[C:4]3[C:9]([C:10]([N:12]4[CH2:16][CH2:15][CH2:14][CH2:13]4)=[CH:11][C:2]([CH3:1])=[N:3]3)=[CH:8][CH:7]=2)[CH2:20][CH2:19]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 81503BromomethylcyclopropaneHCID 1358041182-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol2×

Product 2

HCID 313Hydrochloric AcidHCID 22641355HCID 22641355, compound

Procedure

In analogy to example 3, from 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol, product of example 2, and cyclopropylmethyl bromide—with reaction times of 19 h (0° C.) and isolation of the product as hydrochloride, via treatment of the reaction product with HCl-saturated diethyl ether—there was obtained 7-cyclopropylmethoxy-2-methyl-4-pyrrolidin-1-yl-quinoline hydrochloride as a white solid. ISP mass spectrum, m/e: 283.2 (M+1 calculated for C18H22N2O: 283).

Sources & evidence

ORD record
ord-8d89355b094e472e89cab07b3587d115
Source dataset
uspto-grants-2004_11
Patent number
US06818767B2

Reaction notes

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