Hydrochloric Acid → 2-Methyl-1-phenylpiperaZine hydrochloride

HRID 2416657Notes

Reaction equation

HRID 2416657 reaction equation
[CH3:1][CH:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:21]>C(OCC)(=O)C>[ClH:21].[C:8]1([N:7]2[CH2:6][CH2:5][NH:4][CH2:3][CH:2]2[CH3:1])[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 226330714-Boc-2-methyl-1-phenylpiperazine

Product 1

HCID 226330592-Methyl-1-phenylpiperaZine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

(±)-tert-Butyl 3-methyl-4-phenylpiperazine-1-carboxylate (142 mg) was dissolved in 4N hydrogen chloride in ethyl acetate (5 ml). After stirring for 15 minutes, the solvent was removed under reduced pressure to give the title compound as a slightly yellow solid.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-bad87fa887ec45f383499b68be82f86c
Source dataset
uspto-grants-2004_11
Patent number
US06825200B1

Reaction notes

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