Hydrochloric Acid → HCID 46852043, compound

HRID 241668Notes

Reaction equation

HRID 241668 reaction equation
[CH3:1][N:2]([CH3:28])[CH2:3][CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][C:12]([S:14]([C@H:17]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18]3)(=[O:16])=[O:15])=[CH:13][C:8]=2[N:7]=[C:6]1[CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25].[ClH:29].C(OCC)(=O)C>C(O)C>[ClH:29].[ClH:29].[CH3:1][N:2]([CH3:28])[CH2:3][CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][C:12]([S:14]([C@H:17]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18]3)(=[O:15])=[O:16])=[CH:13][C:8]=2[N:7]=[C:6]1[CH2:23][C:24]([CH3:26])([CH3:25])[CH3:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 46852044HCID 46852044, compound

Product 1

HCID 46852043HCID 46852043, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(S)—N,N-dimethyl-2-(5-(1-methylpyrrolidin-3-ylsulfonyl)-2-neopentyl-1H-benzo[d]imidazol-1-yl)ethanamine (STEP G, 704 mg, 1.73 mmol) was dissolved in ethanol (2 mL). The resulting solution was added 4 mol/L hydrogen chloride in ethyl acetate solution (857 microL, 3.43 mmol) at room temperature. The whole was concentrated in vacuo. The resulting solid was recrystallized from ethanol (4 mL) to give the title compound (413 mg, 50%).

Workup

  1. concentrationThe whole was concentrated in vacuo
  2. customThe resulting solid was recrystallized from ethanol (4 mL)

Sources & evidence

ORD record
ord-2f6d5717e2d04a2793ff471e0443fc2c
Source dataset
uspto-grants-2014_02
Patent number
US08653063B2

Reaction notes

Loading…