Triethylamine → HCID 22633010, compound

HRID 2416790Notes

Reaction equation

HRID 2416790 reaction equation
C(N1C=CN=C1)(N1C=CN=C1)=O.[F:13][C:14]1[CH:31]=[C:30]([F:32])[C:29]([F:33])=[CH:28][C:15]=1[NH:16][C:17]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:18]=1[C:19]([OH:21])=O.Cl.[CH2:35]([O:42][NH2:43])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1.C(N(CC)CC)C>>[F:13][C:14]1[CH:31]=[C:30]([F:32])[C:29]([F:33])=[CH:28][C:15]=1[NH:16][C:17]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:18]=1[C:19]([NH:43][O:42][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:21]

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 102312Benzyloxyamine hydrochlorideHCID 22632910HCID 22632910, compound

Product 1

HCID 22633010HCID 22633010, compoundYield 103.6%

Procedure

Using General Method 2, the reaction of carbonyldiimidazole (2.85 g, 17.6 mmol), 2-(2,4,5-trifluoro-anilino)-4,5-difluorobenzoic acid (Example T, 4.54 g, 14.7 mmol), O-benzylhydroxylamine hydrochloride (2.34 g, 14.7 mmol), and triethylamine (2.45 mL, 17.6 mmol) provided 6.22 g of the crude title compound.

Sources & evidence

ORD record
ord-b37ec7ebce4448308271d79ca3863139
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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