2-Acetylpyrrole → Ethanone, 1-[5-(difluoromethyl)-1H-pyrrol-2-yl]-

HRID 2418854Notes

Reaction equation

HRID 2418854 reaction equation
CC(=O)c1ccc[nH]1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>CC(=O)c1ccc(C(F)F)[nH]1

Participants

7

Reactant 2

HCID 140792-AcetylpyrroleHCID 89600919CID 89600919

Product 1

HCID 84650851Ethanone, 1-[5-(difluoromethyl)-1H-pyrrol-2-yl]-Yield 55%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-86c31c0c6fb344d094ea8fb48dd21358
Source dataset
Minisci dataset from Roche

Reaction notes

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