CID 89600919 → 4-(difluoromethyl)-3-(1-hydroxyethylidene)-4H-chromen-2-one

HRID 2418858Notes

Reaction equation

HRID 2418858 reaction equation
CC(O)=C1Cc2ccccc2OC1=O.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.FC(F)(F)c1ccccc1.O.O=C(O)C(F)(F)F>CC(O)=C1C(=O)Oc2ccccc2C1C(F)F

Participants

7

Reactant 2

HCID 89600919CID 89600919HCID 178465806HCID 178465806, compound

Product 1

HCID 1735107674-(difluoromethyl)-3-(1-hydroxyethylidene)-4H-chromen-2-oneYield 40%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 7368(Trifluoromethyl)benzeneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-aa2f9a3e7ffe436d8ee7b133b29e502d
Source dataset
Minisci dataset from Roche

Reaction notes

Loading…