Methyl Nicotinate → HCID 97181391, compound

HRID 2418880Notes

Reaction equation

HRID 2418880 reaction equation
COC(=O)c1cccnc1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>COC(=O)c1ccc(C(F)F)nc1.COC(=O)c1cccnc1C(F)F.COC(=O)c1cnccc1C(F)F

Participants

9

Reactant 2

HCID 7151Methyl NicotinateHCID 89600919CID 89600919

Product 3

HCID 83854590methyl 6-(difluoromethyl)nicotinateYield 14%HCID 971813861355729-93-9Yield 14%HCID 97181391HCID 97181391, compoundYield 18%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-e2d7b19e412b48f6a6b326f7f606bda6
Source dataset
Minisci dataset from Roche

Reaction notes

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