反应详情

A mixture of 4-phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (6 g; 0.028 mole) (Example 3), o.cyanobenzyl bromide (5.9 g; 0.03 mole) and solid potassium carbonate (5.8 g; 0.042 mole) in dimethylformamide (100 ml) is heated at 70° C during 2 hours. After cooling, the precipitate is filtered and the solvent is evaporated off under reduced pressure. The residue is taken up into water and extracted with ether. The organic extracts are washed with water, dried over sodium sulfate, filtered through a silica bed and evaporated to dryness. The residue is recrystallized from cyclohexane: M.p. = 124° C (Yield: 67%).

1. temperatureAfter cooling
2. filtrationthe precipitate is filtered
3. customthe solvent is evaporated off under reduced pressure
4. extractionextracted with ether
5. washThe organic extracts are washed with water
6. dry with materialdried over sodium sulfate
7. filtrationfiltered through a silica bed
8. customevaporated to dryness
9. customThe residue is recrystallized from cyclohexane