反应详情

温度

155 °C

4-Chloro-6-(1H-indazol-4-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridine 7 (0.040 g, 0.141 mmoles) was dissolved in 2 mL DMF. 3-Methoxyphenol 8e (0.033 g, 0.282 mmol) was added followed by the addition of potassium carbonate (0.2 g, 1.41 mmol). Nitrogen was bubbled through the resultant reaction mixture and heated in a microwave at 155° C. for 1 hour. The reaction mixture was diluted with ethyl acetate and filtered and the organic portions were washed with saturated sodium bicarbonate solution followed by brine, dried over anhydrous sodium sulfate, solvent removed, and purified to obtain the desired product which was to obtain 107 as a white solid (15.0 mg, 30%)

1. customNitrogen was bubbled through the resultant
2. customreaction mixture
3. filtrationfiltered
4. washthe organic portions were washed with saturated sodium bicarbonate solution
5. dry with materialdried over anhydrous sodium sulfate, solvent
6. customremoved
7. custompurified