Benzhydrylpiperazine → HCID 13548819, compound

HRID 2419683Notes

Reaction equation

HRID 2419683 reaction equation
CS[C:3]1[N:8]2[CH:9]=[N:10][CH:11]=[C:7]2[CH:6]=[N:5][N:4]=1.[C:12]1([CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C(C)=CC=CC=1>[C:25]1([CH:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:19]2[CH2:20][CH2:21][N:22]([C:3]3[N:8]4[CH:9]=[N:10][CH:11]=[C:7]4[CH:6]=[N:5][N:4]=3)[CH2:23][CH2:24]2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 70048BenzhydrylpiperazineHCID 12493309HCID 12493309, compound

Product 1

HCID 13548819HCID 13548819, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 6.68 gm of 4-(methylthio)-imidazo[1,5-d]-as-triazine, 15.1 gm of N-diphenylmethylpiperazine and 50 ml of xylene is refluxed for 19 hours. Upon evaporation to dryness, the residue is chromatographed on a silica gel dry column. The product is recrystallized from ethanol and has a melting point equal to 192°-193° C.

Workup

  1. customUpon evaporation to dryness
  2. customthe residue is chromatographed on a silica gel
  3. customdry column
  4. customThe product is recrystallized from ethanol
  5. customequal to 192°-193° C.

Sources & evidence

ORD record
ord-eaa1701156fb48f193a29cacb7dcab2a
Source dataset
uspto-grants-1978_08
Patent number
US04107308

Reaction notes

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