2-Aminothiazole → HCID 178522565, compound

HRID 2419826Notes

Reaction equation

HRID 2419826 reaction equation
[OH:1][C:2]1[C:11]([C:12](OCC)=[O:13])=[C:10]([OH:17])[C:9]2[C:4](=[C:5]([C:18]([F:21])([F:20])[F:19])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:22][C:23]1[S:24][CH:25]=[CH:26][N:27]=1>C1(C)C(C)=CC=CC=1>[S:24]1[CH:25]=[CH:26][N:27]=[C:23]1[NH:22][C:12]([C:11]1[C:2]([OH:1])=[N:3][C:4]2[C:9]([C:10]=1[OH:17])=[CH:8][CH:7]=[CH:6][C:5]=2[C:18]([F:21])([F:20])[F:19])=[O:13]

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 178470066HCID 178470066, compound

Product 1

HCID 178522565HCID 178522565, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 6.02 g of the product of Step C, 200 ml of xylene, 2 g of 2-amino-thiazole and 20 g of siliporite NK20 was refluxed for 2 hours and the resulting product was crystallized from acetic acid to obtain 5.54 g of N-(2-thiazolyl)-2,4-dihydroxy-8-trifluoromethyl-quinoline-3-carboxamide in the form of colorless crystals melting at 260° C.

Workup

  1. temperaturewas refluxed for 2 hours
  2. customthe resulting product was crystallized from acetic acid

Sources & evidence

ORD record
ord-cc831e694d44413c85ca88f7a3ed6764
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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