Diisopropylethylamine → HCID 59025416, compound

HRID 2421082Notes

Reaction equation

HRID 2421082 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C@H:15]2[CH2:20][CH2:19][CH2:18][CH2:17][C@@H:16]2[CH2:21][C:22](O)=[O:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N(C(C)C)CC)(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C>[O:23]=[C:22]1[CH2:21][C@@H:16]2[C@H:15]([CH2:20][CH2:19][CH2:18][CH2:17]2)[N:14]1[CH:11]1[CH2:10][CH2:9][N:8]([C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 59025436HCID 59025436, compound

Product 1

HCID 59025416HCID 59025416, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

((1R,2S)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]amino}cyclohexyl)acetic acid was dissolved in DMF (3 mL) and diisopropyl ethylamine (50 μL) and HATU (0.1 g, 0.26 mmol) was then added and the mixture stirred at room temperature over night. The solvent was then removed under reduced pressure and the mixture was diluted in dichloromethane. Washed with 1N NaOH and with brine and the solvent was then removed under reduced pressure to give the tile compound. MS (M+1): 323.24

Workup

  1. customThe solvent was then removed under reduced pressure
  2. additionthe mixture was diluted in dichloromethane
  3. washWashed with 1N NaOH and with brine
  4. customthe solvent was then removed under reduced pressure
  5. customto give the tile compound

Sources & evidence

ORD record
ord-04600ea21d23465e9f05df48d08ed566
Source dataset
uspto-grants-2011_06
Patent number
US07956069B2

Reaction notes

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