反应详情

A solution of 15.0 g (50.1 mmol) 2-hydroxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester in POCl3 (46 ml) was heated to 100° C. for 2 h. After cooling of the RS to RT, it was diluted with EtOAc and neutralised with a sat. aq. NaHCO3 sol. The organic phase was separated and washed with brine, dried over MgSO4 and concentrated in a vacuum. 15.4 g (48.5 mmol, 97%) 2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester was obtained as a residue. The raw product was further converted without additional purification.

1. customwas separated
2. washwashed with brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated in a vacuum