HCID 86668978, compound → HCID 86668979, compound

HRID 242200Notes

Reaction equation

HRID 242200 reaction equation
[CH3:1][O:2][CH:3]([O:12][CH3:13])/[CH:4]=[C:5](\[CH3:11])/[C:6]([O:8][CH2:9][CH3:10])=[O:7]>CCOC(C)=O.O=[Pt]=O>[CH3:1][O:2][CH:3]([O:12][CH3:13])[CH2:4][CH:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 1

HCID 86668978HCID 86668978, compound

Product 1

HCID 86668979HCID 86668979, compoundYield 66%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution of (E)-ethyl 4,4-dimethoxy-2-methylbut-2-enoate (1.32 g, 7.01 mmol) in EtOAc (30 mL) was added PtO2 (51 mg, 0.22 mmol). The slurry was hydrogenated over night. Filtration trough celite, concentration and purification using silica gel (CH2Cl2-Et2O 1:0 to 0:1) afforded ethyl 4,4-dimethoxy-2-methylbutanoate (0.88 g, 66%).

Workup

  1. waitThe slurry was hydrogenated over night
  2. filtrationFiltration trough celite, concentration and purification

Sources & evidence

ORD record
ord-1ca02aa2d29944e0a6636bc4fd4f76ea
Source dataset
uspto-grants-2014_02
Patent number
US08653112B2

Reaction notes

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