Hydrochloric Acid → 1-(5-Fluoropyridin-2-yl)ethan-1-one

Temperature

-64 °C

5-Fluoro-pyridine-2-carbonitrile (29 g, 240 mmol) was dissolved in THF (150 mL) under a nitrogen atmosphere. The reaction mixture was cooled to an internal temperature of −64° C. Methyl magnesium bromide (3M in THF, 105 mL, 315 mmol) was added over 40 min. The reaction mixture was stirred at −65° C. for 1.5 h, then it was warmed to room temperature. THF (50 mL) was added and the mixture was stirred an additional 3 h. 2M hydrochloric acid (aq., 100 mL) was added until the mixture was slightly acidic and the reaction mixture was stirred at room temperature over night. Sodium bicarbonate was then added to neutralize the reaction mixture. The phases were separated and the aqueous phase was extracted with DCM. The combined organic extracts were washed with Brine, dried over sodium sulphate and concentrated in vacuo. The crude product was purified by flash column chromatography to yield 18 g (55% yield) of the title compound.

1. temperatureit was warmed to room temperature
2. stirringthe mixture was stirred an additional 3 h
3. stirringthe reaction mixture was stirred at room temperature over night
4. customThe phases were separated
5. extractionthe aqueous phase was extracted with DCM
6. washThe combined organic extracts were washed with Brine
7. dry with materialdried over sodium sulphate
8. concentrationconcentrated in vacuo
9. customThe crude product was purified by flash column chromatography

ORD record

ord-36ef662a13c0445aafd83830a7f06247

Source dataset

uspto-grants-2011_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07960395B2