反应详情

A mixture of ethyl [4-(4-phenylbutoxy)phenoxy]acetate (0.59 g, 1.8 mmol), lithium hydroxide monohydrate (0.15 g, 3.6 mmol), tetrahydrofuran (5 mL), methanol (1 mL) and water (3 mL) was stirred at room temperature for 48 hrs. The mixture was acidified with 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was recrystallized from ethyl acetate to give the title compound (0.48 g, yield 89%).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated under reduced pressure
5. customThe residue was recrystallized from ethyl acetate