Methylamine → HCID 11517340, compound

HRID 2422656Notes

Reaction equation

HRID 2422656 reaction equation
[NH2:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:13][NH2:14].[CH3:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1.OC1[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]1.[C:39]1(=O)[CH2:42][CH2:41][CH2:40]1>>[CH3:12][O:11][C:10]1[CH:9]=[CH:8][CH:7]=[C:3]2[C:2]=1[N:1]=[C:21]([C:20]1[CH:23]=[CH:24][C:17]([O:16][CH:15]3[CH2:31][CH2:30][N:29]([CH:39]4[CH2:42][CH2:41][CH2:40]4)[CH2:28][CH2:27]3)=[CH:18][CH:19]=1)[N:14]([CH3:13])[C:4]2=[O:6]

Participants

6

Reactant 5

HCID 6329MethylamineHCID 14496CyclobutanoneHCID 312444-MethoxybenzaldehydeHCID 2557202-Amino-3-methoxybenzoic acidHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 11517340HCID 11517340, compound

Procedure

The entitled compound was obtained according to the method of Example 85 but using 2-amino-3-methoxybenzoic acid, methylamine, 4-methoxybenzaldehyde, tert-butyl 4-hydroxytetrahydro-1(2H)-pyridinecarboxylate, and cyclobutanone. The obtained compound was recrystallized from ethyl acetate-heptane to give a colorless acicular crystal (m.p. 201.0-204.0° C.).

Workup

  1. customThe entitled compound was obtained
  2. customThe obtained compound was recrystallized from ethyl acetate-heptane

Sources & evidence

ORD record
ord-015e8eb4a64041e9b9c278b28fe6d150
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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