Hydrochloric Acid → Hydrochloric Acid

HRID 2425442Notes

Reaction equation

[ClH:1].C(OC(NCCC=O)=O)(C)(C)C.C(=O)C1OC=CC=1.C(OC([NH:28][CH2:29][CH2:30][CH2:31][NH:32][C@@H:33]1[CH2:37][CH2:36][N:35]([S:38]([C:41]2[C:42]3[C:43]([Cl:51])=[CH:44][N:45]=[CH:46][C:47]=3[CH:48]=[CH:49][CH:50]=2)(=[O:40])=[O:39])[CH2:34]1)=O)(C)(C)C>>[NH2:28][CH2:29][CH2:30][CH2:31][NH:32][C@@H:33]1[CH2:37][CH2:36][N:35]([S:38]([C:41]2[C:42]3[C:43]([Cl:51])=[CH:44][N:45]=[CH:46][C:47]=3[CH:48]=[CH:49][CH:50]=2)(=[O:40])=[O:39])[CH2:34]1.[ClH:1]

Participants

Reactant 4

HCID 313Hydrochloric Acid2×

HCID 7362Furfural

HCID 10910051tert-Butyl N-(3-oxopropyl)carbamate

HCID 67245570HCID 67245570, compound

Product 2

HCID 313Hydrochloric Acid

HCID 67241310HCID 67241310, compound

Procedure

Hydrochloride of the compound obtained in Example 19-2 and 3-(tert-butoxycarbonylamino)propionaldehyde can be used in the method of Example 4-1, Step A instead of hydrochloride of the compound prepared in Example 1-1 and furfural, respectively, to prepare (R)-3-[3-(tert-butoxycarbonylamino)propyl]amino-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine, and then the resultant can be used in the method of Example 1, Step B to obtain the title compound as hydrochloride.

Sources & evidence

ORD record: ord-e25acbc5845f4b8d96f4dd7c12a50308
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07964613B2

Reaction notes

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