Hydrochloric Acid → HCID 57579988, compound

HRID 2425446Notes

Reaction equation

C(OC([NH:8][O:9][CH2:10][C:11]([NH:13][C@H:14]1[CH2:18][CH2:17][N:16]([S:19]([C:22]2[C:23]3[C:24]([Cl:32])=[CH:25][N:26]=[CH:27][C:28]=3[CH:29]=[CH:30][CH:31]=2)(=[O:21])=[O:20])[CH2:15]1)=[O:12])=O)(C)(C)C.Cl.C(OC(NOCC(O)=O)=O)(C)(C)C.COCC(O)=O>>[NH2:8][O:9][CH2:10][C:11]([NH:13][C@@H:14]1[CH2:18][CH2:17][N:16]([S:19]([C:22]2[C:23]3[C:24]([Cl:32])=[CH:25][N:26]=[CH:27][C:28]=3[CH:29]=[CH:30][CH:31]=2)(=[O:21])=[O:20])[CH2:15]1)=[O:12]

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 12251Methoxyacetic Acid

HCID 2755974(Boc-aminooxy)acetic acid

HCID 86627813HCID 86627813, compound

Product 1

HCID 57579988HCID 57579988, compound

Procedure

(S)-3-[2-(tert-Butoxycarbonylaminooxy)acetyl]amino-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine can be prepared from hydrochloride of the compound prepared in Example 19-2 by using 2-(tert-butoxycarbonylaminooxy)acetic acid in the method of Example 56-1 instead of 2-methoxyacetic acid, and the protective group of the obtained compound can be removed according to the method described in Example 1-1, Step B to obtain the title compound.

Workup

customthe protective group of the obtained compound can be removed

Sources & evidence

ORD record: ord-ef894517c1f44e7a9f629f9007866714
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07964613B2

Reaction notes

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