Glycol monoacetate → HCID 57422595, compound

HRID 2426764Notes

Reaction equation

HRID 2426764 reaction equation
[C:1]([O:4][CH2:5][CH2:6][OH:7])(=O)[CH3:2].[H-].[Na+].[Br:10][C:11]1[CH:16]=[CH:15]C(F)=C[C:12]=1[C:18]([F:21])([F:20])[F:19]>CN(C=O)C>[Br:10][C:11]1[CH:16]=[CH:15][C:1]([O:4][CH2:5][CH2:6][OH:7])=[CH:2][C:12]=1[C:18]([F:21])([F:20])[F:19]

Participants

5

Reactant 3

HCID 10960Glycol monoacetateHCID 24758Sodium hydrideHCID 5209832-Bromo-5-fluorobenzotrifluoride

Product 1

HCID 57422595HCID 57422595, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In an atmosphere of nitrogen, a mixture of 2-hydroxyethyl acetate, sodium hydride and DMF was stirred at room temperature for 15 minutes and then 1-bromo-4-fluoro-2-(trifluoromethyl)benzene was added, followed by stirring at room temperature for 1.5 hours to obtain 2-[4-bromo-3-(trifluoromethyl)phenoxy]ethanol.

Workup

  1. stirringby stirring at room temperature for 1.5 hours

Sources & evidence

ORD record
ord-911ab615685a4b86bd7485d79867b38c
Source dataset
uspto-grants-2011_06
Patent number
US07968552B2

Reaction notes

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