Potassium Carbonate → HCID 11947986, compound

HRID 2427895Notes

Reaction equation

HRID 2427895 reaction equation
C([N:4]1[C:8]2[CH:9]=[C:10]([C:14]3[N:18]([CH3:19])C4C=CC=CC=4N=3)[CH:11]=[C:12]([CH3:13])[C:7]=2[N:6]=[CH:5]1)CC.Br[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[CH:38]=[O:39])=[CH:28][CH:27]=1.[CH3:40][C:41]([CH3:44])([O-])C.[K+].C(=O)([O-])[O-].[K+].[K+].[OH-].[Na+].[CH3:54][N:55](C)[C:56](=O)C>>[CH2:40]([C:5]1[N:4]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]3[C:33]([CH:38]=[O:39])=[CH:34][CH:35]=[CH:36][CH:37]=3)=[CH:28][CH:27]=2)[C:8]2[CH:9]=[C:10]([C:14]3[N:18]=[CH:19][N:55]([CH3:56])[CH:54]=3)[CH:11]=[C:12]([CH3:13])[C:7]=2[N:6]=1)[CH2:41][CH3:44]

Participants

7

Reactant 6

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 31374DimethylacetamideHCID 11947984HCID 11947984, compoundHCID 23665647Potassium tert-butoxideHCID 86637438HCID 86637438, compound

Product 1

HCID 11947986HCID 11947986, compound

Procedure

A typical but not limiting example represents a reaction of 2-(1-propyl-4 methyl-6-(1′-methylbenzimidazole-2-yl)benzimidazole with 4-bromomethyl-2′-formylbiphenyl in N,N-dimethylacetamide with potassium tert-butoxide or potassium carbonate or sodium hydroxide as a base to give 4′-[(2-n-propyl-4-methyl-6-(1-methyl-imidazol-4-yl)-benzimidazol-1-yl)methyl]-biphenyl-2-carboxaldehyde. In another typical but not limiting example 4-bromomethyl-2′-formylbiphenyl reacts in similar conditions with 2-butyl-4,4-tetramethylene-4,5-dihydroimidazol-5-one to give 2-butyl-4,5-dihydro-1-((2′-formyl-4-biphenylyl)methyl)-4,4-tetramethyleneimidazol-5-one.

Sources & evidence

ORD record
ord-838920ed2c634b84b71c73733bd7fa22
Source dataset
uspto-grants-2011_06
Patent number
US07968727B2

Reaction notes

Loading…