反应详情

温度

70 °C

A mixture of compound C6 (1.00 g, 1.86 mmol) and aq. 1M LiOH (7.00 mL, 7.00 mmol) in THF (7.00 mL) was stirred at 70° C. overnight. Aq. 1M HCl was added until a pH of 4 was reached, and the mixture was extracted with EtOAc (3×). The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying under high vacuum yielded the crude title compound mixed with 6-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-3′,6′-dihydro-2′H-[3,4′]bipyridinyl-1′,3′-dicarboxylic acid 1′-tert-butyl ester (850 mg, 87%) that was used further without purification.

1. extractionthe mixture was extracted with EtOAc (3×)
2. dry with materialextracts were dried over MgSO4
3. filtrationfiltered
4. customthe solvents were removed under reduced pressure
5. customDrying under high vacuum