反应详情

温度

5 °C

10.0 g crystal form IV of erlotinib base was added to 200 ml ethyl formate, heated to 0-10° C., 6.4 g isopropanol saturated with HCl gas was added dropwise, after dripping, stirred for 30 minutes while maintaining the temperature, stirred for 1 hour at 0-15° C. before filtration, dried at 50° C. to obtain 10.2 g sample of crystal form A. The yield was 93.6% and the purity was 99.7% (by HPLC).

1. temperaturewhile maintaining the temperature
2. stirringstirred for 1 hour at 0-15° C. before filtration
3. customdried at 50° C.
4. customto obtain 10.2 g sample of crystal form A